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Towards a 3D-Printed Millifluidic Device for Investigating Cellular Processes.

Jared A Engelken1, Tobias Butelmann1, Fabian Tribukait-Riemenschneider1

  • 1Institute for Macromolecular Chemistry, University of Freiburg, 79104 Freiburg, Germany.

Micromachines
|November 27, 2024
PubMed
Summary
This summary is machine-generated.

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3D printing enables cost-effective production of millifluidic devices (MiFDs) for disease modeling. These devices offer a rapid prototyping alternative to microfluidic devices (µFDs), facilitating cancer research and drug screening.

Area of Science:

  • Biomedical Engineering
  • 3D Printing Technology
  • Disease Modeling

Background:

  • Microfluidic devices (µFDs) are valuable for drug screening and studying cellular processes but face fabrication challenges.
  • Light-based 3D printing presents a viable alternative for creating micro- and millifluidic devices.
  • Millifluidic devices (MiFDs) offer a scalable and potentially more accessible approach to disease modeling.

Purpose of the Study:

  • To develop and characterize 3D-printed millifluidic devices (MiFDs) for disease modeling.
  • To demonstrate the cost-efficiency and ease of production of MiFDs using 3D printing.
  • To assess the suitability of MiFDs for cancer research and studying cellular processes.

Main Methods:

  • Iterative design and development of MiFDs using stereolithography (SLA) 3D printing.
Keywords:
3D printingAI-enabled designcancer researchmetastasismillifluidicsorgan-on-a-chipstereolithography

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  • Analytical testing including flow tests, leak tests, and cytotoxicity assays.
  • Microscopic analyses to evaluate cell culturing and interstitial flow replication.

    • Main Results:

    • Successfully designed and produced 3D-printed MiFDs with essential attributes for cell culturing.
    • Identified cytotoxic potential in the primary SLA resin despite biocompatibility claims, necessitating careful material selection.
    • Demonstrated the ability of MiFDs to replicate interstitial flow relevant to tissue environments.

    Conclusions:

    • Stereolithography (SLA) 3D printing provides a cost-effective and rapid prototyping method for producing MiFDs.
    • MiFDs serve as a practical alternative to traditional µFDs for disease modeling and cancer research.
    • Further material optimization is needed to fully leverage the potential of 3D-printed devices in biological applications.