Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 6, 2025

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

Published on: August 30, 2007

Towards a 3D-Printed Millifluidic Device for Investigating Cellular Processes.

Jared A Engelken¹, Tobias Butelmann¹, Fabian Tribukait-Riemenschneider¹

¹Institute for Macromolecular Chemistry, University of Freiburg, 79104 Freiburg, Germany.

|November 27, 2024

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma-Like Transcriptional Programs in Astrocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

Double-Network Polysaccharide-Collagen Hybrid Bioink.

ACS applied materials & interfaces·2025

Same author

Comparative Analysis of Dimensional Accuracy in PLA-Based 3D Printing: Effects of Key Printing Parameters and Related Variables.

Polymers·2025

Same author

Incorporation of Cross-Linked Gelatin Microparticles To Enhance Cell Attachment and Chondrogenesis in Carboxylated Agarose Bioinks for Cartilage Engineering.

ACS applied materials & interfaces·2025

Same author

Sulfated and Phosphorylated Agarose as Biomaterials for a Biomimetic Paradigm for FGF-2 Release.

Biomimetics (Basel, Switzerland)·2025

Same author

Modulation of Short-Term Delivery of Proteins from Hydrogels.

ACS applied materials & interfaces·2024

3D printing enables cost-effective production of millifluidic devices (MiFDs) for disease modeling. These devices offer a rapid prototyping alternative to microfluidic devices (µFDs), facilitating cancer research and drug screening.

Area of Science:

Biomedical Engineering
3D Printing Technology
Disease Modeling

Background:

Microfluidic devices (µFDs) are valuable for drug screening and studying cellular processes but face fabrication challenges.
Light-based 3D printing presents a viable alternative for creating micro- and millifluidic devices.
Millifluidic devices (MiFDs) offer a scalable and potentially more accessible approach to disease modeling.

Purpose of the Study:

To develop and characterize 3D-printed millifluidic devices (MiFDs) for disease modeling.
To demonstrate the cost-efficiency and ease of production of MiFDs using 3D printing.
To assess the suitability of MiFDs for cancer research and studying cellular processes.

Main Methods:

Iterative design and development of MiFDs using stereolithography (SLA) 3D printing.

Keywords:

3D printing AI-enabled design cancer research metastasis millifluidics organ-on-a-chip stereolithography

More Related Videos

A Gradient-generating Microfluidic Device for Cell Biology

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Related Experiment Videos

Last Updated: Jun 6, 2025

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

A Microfluidic Device with Groove Patterns for Studying Cellular Behavior

Published on: August 30, 2007

A Gradient-generating Microfluidic Device for Cell Biology

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Analytical testing including flow tests, leak tests, and cytotoxicity assays.

Microscopic analyses to evaluate cell culturing and interstitial flow replication.

Main Results:

Successfully designed and produced 3D-printed MiFDs with essential attributes for cell culturing.
Identified cytotoxic potential in the primary SLA resin despite biocompatibility claims, necessitating careful material selection.
Demonstrated the ability of MiFDs to replicate interstitial flow relevant to tissue environments.

Conclusions:

Stereolithography (SLA) 3D printing provides a cost-effective and rapid prototyping method for producing MiFDs.
MiFDs serve as a practical alternative to traditional µFDs for disease modeling and cancer research.
Further material optimization is needed to fully leverage the potential of 3D-printed devices in biological applications.