Related Experiment Video
Updated: Jun 6, 2025
07:32
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
7.0K
Aging-Induced Changes in Cutibacterium acnes and Their Effects on Skin Elasticity and Wrinkle Formation
YeonGyun Jung1, Ikwhan Kim2, Da-Ryung Jung3
1Burn Institute, Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul 07247, Republic of Korea.
Microorganisms
|November 27, 2024
Summary
The aging skin microbiome, with less Cutibacterium acnes (C. acnes), shows reduced elasticity and more wrinkles. C. acnes may have anti-aging effects, influencing skin health.
Area of Science:
- Microbiology
- Dermatology
- Gerontology
Background:
- Skin aging is characterized by biomechanical changes, including reduced elasticity and increased wrinkles.
- The skin microbiome plays a crucial role in modulating skin aging processes.
- Alterations in microbial composition, such as decreased Cutibacterium acnes (C. acnes) abundance, are associated with aging skin.
Purpose of the Study:
- To investigate the impact of reduced C. acnes abundance and increased microbial diversity on skin biomechanical properties in relation to aging.
- To compare the skin microbiome composition and function between younger and older individuals.
- To explore the potential anti-aging effects of C. acnes.
Main Methods:
- Recruited 60 healthy Korean participants (20-29 years and 60-75 years).
- Performed metagenomic sequencing to analyze skin microbiome composition.
- Conducted skin assessments to evaluate biomechanical properties and wrinkle formation.
Main Results:
- Older individuals showed decreased C. acnes dominance and higher microbial diversity, correlating with reduced skin elasticity and increased wrinkles.
- Functional analysis revealed distinct metabolic pathways enriched in younger (zeatin biosynthesis, biotin metabolism) versus older (lipid metabolism, response to UV/pollution) groups.
- Network analysis indicated greater microbial connectivity and stability in younger individuals, while older individuals exhibited higher modularity.
Conclusions:
- Changes in skin microbiome composition, specifically reduced C. acnes, are linked to diminished skin elasticity and increased wrinkles associated with aging.
- The skin microbiome's functional pathways differ significantly between age groups, reflecting adaptations to aging and environmental factors.
- C. acnes may possess anti-aging properties, warranting further investigation into its physiological mechanisms and therapeutic potential for skin health.
Related Concept Videos
01:19The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
01:12Renewal of Skin Epidermal Stem Cells
2.5K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K
01:29Bone Disorders
3.4K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.4K
01:26Aging
37
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
37