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Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective.

Mubashar Rehman1, Nayab Tahir2,3, Muhammad Farhan Sohail4,5

  • 1Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Pharmaceutics
|November 27, 2024
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Summary

Lipid-based nanoparticles and vesicular systems enhance the solubility and absorption of water-insoluble drugs. These advanced delivery systems offer controlled release and targeted delivery for various therapeutics.

Keywords:
SLNcontrolled releasehydrophobicliposomespeptideself-emulsifyingsolubility enhancementtargetingvaccine

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Oils and lipids, with surfactants, improve water-insoluble drug solubility and absorption.
  • Microemulsions, nanoemulsions, and self-emulsifying drug delivery systems offer stability and controlled release.
  • Solid lipid nanoparticles and liposomes/niosomes enable enhanced drug loading and targeted delivery.

Purpose of the Study:

  • To review lipid and oil-based nanoparticulate systems for water-insoluble drug delivery.
  • To highlight the features of various systems like emulsions, solid lipid nanoparticles, liposomes, and niosomes.
  • To emphasize comparative studies on these drug delivery systems.

Main Methods:

  • Review of scientific literature on lipid-based drug delivery systems.
  • Analysis of the structural manipulation of emulsions and nanoparticles.
  • Examination of phospholipid and surfactant-based vesicular systems.

Main Results:

  • Lipid systems effectively enhance the solubility and absorption of poorly soluble drugs.
  • Nanoparticulate systems provide prolonged storage and controlled drug release.
  • Multifunctional nanoparticles can encapsulate macromolecules like proteins and nucleic acids.

Conclusions:

  • Lipid nanoparticles and vesicular systems are increasingly preferred for therapeutic agent encapsulation and delivery.
  • Advancements in targeting ligands and synthetic lipids will further enhance these systems.
  • Comparative studies are crucial for selecting optimal lipid-based delivery strategies.