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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Updated: Jun 18, 2026

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications
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Single-Component Starch-Based Hydrogels for Therapeutic Delivery.

Alfio Pulvirenti1, Antonella Caterina Boccia1, Carolina Constantin2,3

  • 1Istituto di Scienze e Tecnologie Chimiche (SCITEC) "Giulio Natta", C.N.R., Via Alfonso Corti 12, 20133 Milano, Italy.

Molecules (Basel, Switzerland)
|November 27, 2024
PubMed
Summary

New starch-based hydrogels offer controlled drug delivery. These biodegradable materials show potential for precise therapeutic applications by managing cell proliferation and release kinetics.

Keywords:
NMRcytotoxicityflow cytometryhydrogelsstarchtherapeutic delivery

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogels are effective drug delivery systems due to their water-swollen networks enabling sustained release.
  • Starch-based materials are attractive due to their biocompatibility and biodegradability.
  • Developing novel hydrogels with controlled degradation and therapeutic molecule integration is crucial.

Purpose of the Study:

  • To synthesize single-component, starch-based hydrogels with enhanced degradation rates.
  • To propose these hydrogels as a novel delivery system for therapeutic molecules.
  • To evaluate the structural, morphological, release, and cytotoxic properties of the synthesized hydrogels.

Main Methods:

  • Starch oxidation using sodium periodate followed by a freeze-thaw procedure to form hydrogels.
  • Cross-linking of oxidized starch with asparagine via Schiff base reaction for therapeutic molecule linkage.
  • Structural and morphological characterization, quantitative Nuclear Magnetic Resonance (qNMR) for drug adsorption/release studies, and cytotoxicity assays on CAL-27 cell line.

Main Results:

  • Facile synthesis yielded stable, single-component starch-based hydrogels with tunable degradation rates.
  • Successful adsorption and sustained release of an active molecule were confirmed by qNMR.
  • Cytotoxicity evaluation showed hydrogels induced a "frozen proliferative" state in CAL-27 cells, with increased late apoptosis compared to controls.

Conclusions:

  • Synthesized starch-based hydrogels demonstrate potential as advanced drug delivery platforms.
  • The ability to control cell proliferation and release kinetics offers a new avenue for precise therapeutic applications.
  • These materials represent a promising development in biodegradable hydrogel technology for targeted therapies.