Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment.

S L Welle, R G Campbell

    Metabolism: Clinical and Experimental
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Work-related musculoskeletal disorders in endoscopic sinus and skull base surgeons: an international survey.

    Rhinology·2026
    Same author

    Outcome measures for chronic rhinosinusitis with nasal polyps.

    Rhinology·2024
    Same author

    Features of inhalant allergy on nasal endoscopy: a systematic review and meta-analysis.

    Rhinology·2022
    Same author

    Phosphaturic Mesenchymal Tumors in the Head and Neck Demonstrate a Broad Clinical and Morphologic Spectrum.

    Head and neck pathology·2022
    Same author

    Imidazoline use in sinonasal surgery.

    Medical hypotheses·2014
    Same author

    Reducing the length of time between slaughter and the secondary gonadotropin-releasing factor immunization improves growth performance and clears boar taint compounds in male finishing pigs.

    Journal of animal science·2011

    Reduced thyroid hormone (T3) levels contribute to lower resting metabolic rate (RMR) during rapid weight loss. Thyroid hormone replacement partially restored RMR but did not fully normalize it in obese subjects on a very low energy diet.

    Area of Science:

    • Endocrinology
    • Metabolism
    • Nutrition Science

    Background:

    • Rapid weight loss, often achieved through very low energy diets, can lead to a decrease in resting metabolic rate (RMR).
    • Serum concentrations of thyroid hormones, particularly triiodothyronine (T3), are known to decrease during periods of caloric restriction and weight loss.

    Purpose of the Study:

    • To investigate whether reduced serum T3 concentrations are a contributing factor to the decline in RMR observed during rapid weight loss.
    • To assess the effects of thyroid hormone (T3 and T4) replacement on RMR in obese subjects undergoing a very low energy diet.

    Main Methods:

    • Obese subjects were placed on a very low energy diet, and their RMR and serum thyroid hormone levels were monitored.
    • Thyroid hormone replacement therapy (T3 and T4) was administered to assess its impact on RMR and hormone concentrations.

    Related Experiment Videos

  • Measurements were taken before, during, and after the thyroid hormone replacement period.

    • Main Results:

    • During the initial two weeks of weight loss, RMR decreased to 86% of baseline, coinciding with a T3 concentration drop to 72% of baseline.
    • One week of thyroid hormone replacement increased RMR to 94% of baseline and elevated serum T3 and T4 to approximately 130% of baseline.
    • A second week of thyroid treatment did not result in further RMR changes.

    Conclusions:

    • Reduced serum T3 concentrations play a role in the decrease of RMR during rapid weight loss.
    • Thyroid hormone replacement therapy partially improved RMR in obese subjects on a very low energy diet but did not fully restore it to normal levels.
    • The study highlights the complex interplay between thyroid hormones, energy metabolism, and weight loss.