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Microfluidic Picoliter Bioreactor for Microbial Single-cell Analysis: Fabrication, System Setup, and Operation

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Published on: December 6, 2013

A Microfluidic-Based Sensing Platform for Rapid Quality Control on Target Cells from Bioreactors.

Alessia Foscarini^1,2, Fabio Romano³, Valeria Garzarelli^1,2,4

¹CNR Nanotec Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy.

Sensors (Basel, Switzerland)

|November 27, 2024

Summary

This summary is machine-generated.

A new Lab-On-a-Chip (LoC) system offers automated quality control for cancer immunotherapy cells. This reliable, low-cost device uses a capacitive sensor for accurate cell detection, improving efficiency and affordability in cell therapy.

Keywords:

CAR-T quality control capacitive sensor cell detection lab-on-chip on-chip sensor

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Area of Science:

Biotechnology
Medical Devices
Cancer Research

Background:

Immunotherapy, utilizing Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs), is a promising cancer treatment.
Current immunotherapy requires manual, labor-intensive, and error-prone quality control of engineered cells.
Automated solutions are needed to improve the efficiency and scalability of cell therapy.

Purpose of the Study:

To design and characterize a Lab-On-a-Chip (LoC) system for automated cell detection and quality control.
To develop a cost-effective, reliable, and miniaturized device to support immunotherapy.
To integrate cell detection as a building block for future LoC systems in immunotherapy.

Main Methods:

A Lab-On-a-Chip (LoC) device featuring an integrated capacitive sensor managed by a microcontroller was developed.
The system detects cells by measuring charge variations without requiring an external AC source.
Characterization involved using a gold nanoparticle-labeled cell line, tested in both drop and microfluidic channel formats.

Main Results:

The LoC system demonstrated good sensitivity, detecting as few as approximately 120 cells.
The device utilizes standardized components for potential mass manufacturing and is suitable for bioreactor integration.
Experiments showed reliable cell detection in both microfluidic and non-microfluidic setups.

Conclusions:

The developed LoC system provides a simple, low-cost, and reliable solution for automated cell detection.
This technology has the potential to replace manual procedures, increasing throughput and affordability in immunotherapy.
The LoC device's applicability extends beyond immunotherapy to various cell detection contexts.