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Graham-Little-Piccardi-Lassueur Syndrome with Mucosal Involvement: A Rare Case.

Rutoo Vipulkumar Polra¹, Jinal Jainendrabhai Tandel², Pragya Ashok Nair¹

¹Department of Dermatology, Shree Krishna Hospital, Bhaikaka University, Karamsad, Gujarat, India.

International Journal of Trichology

|November 27, 2024

Summary

Graham-Little-Piccardi-Lassueur syndrome (GLPLS), a form of lichen planopilaris, affects middle-aged women. Early diagnosis is crucial to prevent irreversible scarring alopecia.

Keywords:

Cicatricial alopecia Graham-Little-Piccardi-Lassueur syndrome dermoscopy follicular plugging

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Area of Science:

Dermatology
Pathology

Background:

Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare variant of lichen planopilaris.
It primarily impacts females aged 40-60, presenting with a distinct clinical triad.

Observation:

The syndrome is characterized by patchy scarring scalp alopecia, non-scarring axillary and groin alopecia, and follicular papules.
A case in a 73-year-old female exhibited classical clinical, dermoscopic, and histopathological features.

Findings:

Diagnosis relies on correlating clinical presentation with histopathological findings.
Treatment options currently yield unsatisfactory responses, underscoring the need for timely intervention.

Implications:

Early identification of GLPLS is essential to mitigate disease progression and permanent hair loss.
This case highlights the importance of comprehensive evaluation for diagnosing GLPLS.