Polymer lipid hybrid nanoparticles for phytochemical delivery: challenges, progress, and future prospects

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Pharmacology

Background:

• Phytochemicals exhibit diverse therapeutic properties but face delivery challenges like poor solubility and low bioavailability.
• Conventional delivery methods limit the clinical efficacy of plant-derived compounds.

Purpose of the Study:

• To review the potential of polymer lipid hybrid nanoparticles (PLHNPs) for enhanced phytochemical delivery.
• To explore PLHNPs as a strategy to overcome the limitations of traditional phytochemical administration.

Main Methods:

• Discussion of PLHNPs architecture, types, and surface modification strategies.
• Review of preclinical studies on phytochemical-loaded PLHNPs for disease management.

Main Results:

• PLHNPs improve encapsulation efficiency, stability, and controlled release of phytochemicals.
• Surface modifications enhance site-specific delivery and overall therapeutic efficacy.
• Preclinical data indicate efficacy in managing various diseases.

Conclusions:

• PLHNPs represent a potent delivery system for improving phytochemical bioavailability and therapeutic outcomes.
• Further research and development are needed for widespread clinical application of phytochemical-loaded PLHNPs.