Advances in radical peroxidation with hydroperoxides

Area of Science:

• Organic Chemistry
• Synthetic Chemistry

Background:

• Organic peroxides are crucial functionalities in polymer production and medicinal chemistry.
• Selective introduction of peroxide fragments is a key challenge in modern synthetic design.

Purpose of the Study:

• To review recent advancements in radical Kharasch-type functionalization for introducing the organic peroxide (OOR) group.
• To discuss the application of these methods across various substrate types.

Main Methods:

• Focuses on radical peroxidation reactions, particularly Kharasch-type methods.
• Includes discussion of free-component radical couplings.
• Organizes findings based on substrate: C(sp)-H, aromatic, and unsaturated systems.

Main Results:

• Summarizes progress in selective peroxidation of diverse organic molecules.
• Highlights the versatility of radical coupling for generating molecular complexity.
• Demonstrates the utility of Kharasch-type reactions for various substrate classes.

Conclusions:

• Radical Kharasch-type peroxidation offers a powerful platform for synthesizing organic peroxides.
• Recent advances have expanded the scope and selectivity of these reactions.
• This methodology is valuable for accessing complex molecules in various chemical fields.