Beck Depression Inventory-II Response Following Parathyroidectomy for Primary Hyperparathyroidism: A Systematic...

Area of Science:

• Endocrinology
• Neurosurgery
• Psychiatry

Background:

• Neuropsychiatric symptoms in primary hyperparathyroidism (pHPT) lack clear surgical guidelines.
• Depression is a common symptom impacting pHPT patient quality of life.

Purpose of the Study:

• To systematically review and meta-analyze Beck Depression Inventory-II (BDI-II) scores in pHPT patients before and after parathyroidectomy.
• To evaluate the efficacy of parathyroidectomy in improving depressive symptoms in pHPT.

Main Methods:

• Comprehensive literature search across Embase, PubMed, Web of Science, PsycINFO, and OvidAll EBM Reviews.
• Inclusion of studies reporting BDI-II scores in pHPT patients pre- and post-parathyroidectomy.
• Meta-analysis of BDI-II scores to determine changes in depression levels.

Main Results:

• Nine studies met inclusion criteria from 1554 initially identified.
• pHPT patients exhibited significantly higher baseline BDI-II scores than controls.
• A statistically significant reduction in BDI-II scores was observed at 1 and 6 months post-surgery.

Conclusions:

• Parathyroidectomy leads to significant improvement in depressive symptoms for pHPT patients.
• A Beck Depression Inventory-II score of 14 or greater may serve as a potential indicator for considering parathyroidectomy in pHPT management.