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Opiate Use Patterns Following Surgery for High Grade Glioma
Grace Hey1, Phuong Deleyrolle2, Abeer Dagra2
1College of Medicine, University of Florida, Gainesville, Florida, USA.
World Neurosurgery
|November 27, 2024
Summary
Postoperative opiate use after craniotomy for high-grade glioma was modest, with male sex and tobacco use linked to higher immediate pain medication needs. History of pain syndrome increased renewal odds, while age decreased them.
Area of Science:
- Neurosurgery
- Oncology
- Pain Management
Background:
- Opiates are standard for postoperative pain after craniotomy.
- High-grade gliomas often require surgical intervention.
- Understanding opiate use patterns is crucial for optimizing patient recovery.
Purpose of the Study:
- To evaluate opiate consumption in patients undergoing craniotomy for high-grade glioma.
- To identify predictors of prolonged opiate use in this patient population.
Main Methods:
- Retrospective chart review of adult patients (2016-2020).
- Data collected included pain history, substance use, and opiate dosage (Morphine Equivalent Dose - MED).
- Statistical analysis performed using R software.
Main Results:
- 295 patients included; 73.6% underwent resection.
- Average immediate postoperative MED/day was 20.3; average outpatient use was 15.1 days.
- Male sex and tobacco use correlated with higher MED/day. Pain history increased renewal odds; age decreased them.
Conclusions:
- Postoperative opiate use in this cohort was generally modest.
- Comorbidities like male sex, tobacco use, and pain history influence opiate requirements.
- Further prospective research is recommended for stronger evidence.
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