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Updated: Jun 6, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Remote Alkynylation of Aliphatic Amines

Elizabeth M Dauncey1, Tom D Sheppard2, Peter D Smith1

  • 1Early Chemical Development, Pharmaceutical Sciences R&D, AstraZeneca, Macclesfield, SK10 2NA, U.K.

Organic Letters
|November 27, 2024
PubMed
Summary

Researchers developed a new palladium-catalyzed method for alkynylating aliphatic amines. This advance expands synthetic chemistry tools, enabling new ways to create complex molecules with the remote alkynylation of amines.

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