Related Experiment Video
Updated: Jun 6, 2025
11:31
Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
Published on: October 31, 2012
15.8K
Histomorphometric outcome following sinus floor augmentation with allogeneic adipose tissue-derived stem cells. A
Thomas Starch-Jensen1, Hanna Aludden2, Christer Dahlin2
1Department of Oral and Maxillofacial Surgery, Aalborg University Hospital and Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark.
Summary
Adding allogeneic adipose-derived stem cells (AASCs) to deproteinized bovine bone mineral (DBBM) for sinus floor augmentation (SFA) did not improve new bone formation or bone-to-implant contact compared to DBBM alone in a preclinical study.
Area of Science:
- Dental Implantology
- Regenerative Medicine
- Biomaterials Science
Background:
- Sinus floor augmentation (SFA) is a common procedure to increase bone volume for dental implants.
- Allogeneic adipose-derived stem cells (AASCs) show potential in bone regeneration.
- Deproteinized bovine bone mineral (DBBM) is a widely used bone graft material.
Purpose of the Study:
- To evaluate the efficacy of AASCs combined with DBBM for SFA.
- To compare histomorphometric outcomes of SFA using AASCs/DBBM versus DBBM alone.
Main Methods:
- A pre-clinical study involving 18 minipigs.
- Sinus augmentation performed with either AASCs on DBBM (test) or excipient on DBBM (control).
- Histomorphometric analysis of newly formed bone (NFB) and bone-to-implant contact (BIC) at 1, 2, and 4 months.
Main Results:
- No significant differences in NFB or BIC between the test and control groups at any time point.
- Significant increases in NFB were observed over time in both groups.
- Bone-to-implant contact (BIC) remained stable across all time points for both groups.
Conclusions:
- Allogeneic adipose-derived stem cells (AASCs) do not appear to enhance new bone formation or bone-to-implant contact when used with deproteinized bovine bone mineral (DBBM) for sinus floor augmentation.
- DBBM alone supports bone regeneration in SFA procedures.
- Further research may be needed to explore alternative stem cell sources or delivery methods.
