Related Experiment Video
Updated: Jun 6, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
463
Exploring NNMT: from metabolic pathways to therapeutic targets.
Jeongwoo Park1,2,3, Eun Jin Shin2,3,4, Tae Hyun Kim5
1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Archives of Pharmacal Research
|November 28, 2024
Summary
Nicotinamide N-methyltransferase (NNMT) links cellular metabolism and epigenetics. This review explores NNMT
Area of Science:
- Biochemistry
- Epigenetics
- Metabolic pathways
Background:
- Cellular homeostasis relies on metabolism-linked epigenetic regulation.
- Nicotinamide N-methyltransferase (NNMT) is a key enzyme connecting cellular metabolism and epigenetics.
- NNMT catalyzes nicotinamide methylation, linking one-carbon metabolism and NAD+ levels.
Purpose of the Study:
- To review the diverse roles of NNMT in various pathological conditions.
- To elucidate the cellular mechanisms of NNMT in disease.
- To provide a foundation for developing NNMT-targeted therapies.
Main Methods:
- Literature review of studies on NNMT expression, activity, and function.
- Synthesis of information on NNMT's involvement in different diseases.
- Analysis of NNMT's role in cellular homeostasis and disease pathogenesis.
Main Results:
- NNMT exhibits tissue-specific expression and activity.
- NNMT is implicated in cancer, liver disease, obesity, diabetes, brain, pulmonary, cardiovascular, and kidney diseases.
- Dysregulation of NNMT contributes to various pathological processes.
Conclusions:
- NNMT is a critical regulator of cellular metabolism and epigenetics with broad implications in disease.
- Understanding NNMT's tissue-specific roles is crucial for therapeutic development.
- Targeting NNMT offers potential for novel pharmacological interventions across multiple disease areas.
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