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Published on: May 4, 2018
The Relationship Between Preoperative Vitamin D Levels and Keloid Recurrence
Da Woon Lee1, Daihun Kang2, Boram Ha3
1Department of Plastic and Reconstructive Surgery, College of Medicine, Soonchunhyang University, Cheonan, Republic of Korea.
Background:
Keloids, characterized by excessive collagen deposition, often recur despite various treatments. This study explores the association between preoperative serum vitamin D levels and keloid recurrence in a Korean population.
Methods:
A retrospective cohort of 160 patients who underwent keloid excision was analyzed. Preoperative serum 25(OH) vitamin D and 1,25(OH)2 vitamin D levels were measured. Recurrence rates were compared using hierarchical logistic regression, adjusting for potential confounders.
Results:
Age was significantly associated with keloid recurrence (OR: 0.934, p = 0.009), indicating older age was linked to lower recurrence risk. No significant association was found between preoperative 25(OH) vitamin D (p = 0.395) and 1,25(OH)2 vitamin D levels (p = 0.925) and keloid recurrence.
Conclusions:
Preoperative vitamin D levels do not predict keloid recurrence in this Korean cohort, while age is a significant predictor. Understanding the multifactorial nature of keloid pathogenesis requires further investigation into other potential risk factors.
