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Updated: Aug 14, 2026

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
08:40

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions

Published on: June 23, 2022

Structural basis of α-synuclein and DJ-1 complex

Hyeon Jin Kim1, Da Hye Kim2, Chang Woo Han1

  • 1Institute of Systems Biology, Pusan National University, Jangjeon-dong, Geumjeong-gu, Busan, 46241, Republic of Korea.

International Journal of Biological Macromolecules
|August 12, 2026
PubMed
Summary

DJ-1 directly interacts with alpha-synuclein, inhibiting its aggregation into toxic fibrils. A DJ-1-derived peptide shows therapeutic potential for alpha-synucleinopathies like Parkinson's disease dementia.

Keywords:
ComplexDJ-1X-ray crystallographyα-Synuclein

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