Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

First-order field autocorrelation function analysis-based dynamic OCT for tissue viability assessment.

Biomedical optics express·2026

Same author

Icariin Alleviates Diabetes-Associated Cognitive Dysfunction Through Modulation of LCN2-MEK/ERK Signaling-Associated Neuroinflammation.

CNS neuroscience & therapeutics·2026

Same author

Ostwald Ripening of Liquid-Metal-Grown Micropattern-Confined Crystals by Solid-Phase Diffusion.

Nano letters·2026

Same author

Gallium in liquid state shows nuclease-mimicking activity.

Nature communications·2026

Same author

A nationwide cross-sectional survey of major allergic diseases in China during 2010-2015 involving 120,000 participants.

Scientific reports·2026

Same author

Learned feature-based clustering of brain tissue with multimodal optical coherence tomography and photoacoustic elastography.

Optics letters·2026

Search research articles

Related Experiment Video

Updated: Jun 6, 2025

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Published on: November 19, 2012

1550 Nm Optical Coherence Tomography for In Vivo Deep Brain Cerebral Blood Flow Imaging.

Wei Chen¹, Xiangsen Guo¹, Junxiong Zhou¹

¹Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, China.

Journal of Biophotonics

|November 28, 2024

Summary

This study explores using 1550 nm optical coherence tomography (OCT) for deep brain imaging. Despite water absorption, this cost-effective method shows promise for visualizing cerebral vasculature and blood flow.

Keywords:

cerebral blood flow velocity cerebral vasculature dynamic light scattering optical coherence tomography (DLSOCT)optical coherence tomography angiography (OCTA)

More Related Videos

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Related Experiment Videos

Last Updated: Jun 6, 2025

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Published on: November 19, 2012

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy

Published on: May 27, 2020

Area of Science:

Biomedical Optics
Neuroimaging
Optical Coherence Tomography

Background:

Longer wavelengths enhance deep penetration in optical imaging.
The 1550 nm spectrum is often avoided in biological imaging due to high water absorption.
Optical Coherence Tomography (OCT) is a non-invasive imaging technique.

Purpose of the Study:

To investigate the feasibility of 1550 nm OCT for imaging mouse brain cortex vasculature and blood flow.
To compare the performance of 1550 nm OCT with a commercial 1310 nm OCT system.
To assess the potential of 1550 nm OCT for deep brain cerebral hemodynamics imaging.

Main Methods:

Development and application of a 1550 nm center wavelength OCT system.
Comparative imaging of mouse brain cortex vasculature and blood flow.
Evaluation of signal attenuation and blood flow imaging capabilities.

Main Results:

The 1550 nm OCT system showed greater signal attenuation in deeper regions compared to 1310 nm OCT.
Similar blood flow imaging results were obtained across all cortex layers for both systems.
The 1550 nm OCT system demonstrated comparable performance in blood flow imaging.

Conclusions:

1550 nm OCT is feasible for imaging cerebral vasculature and blood flow in the mouse brain cortex.
While deeper penetration is reduced, 1550 nm OCT offers similar blood flow insights.
The lower cost of 1550 nm components makes it a potentially favorable option for deep brain hemodynamics research.