A Ten Year Review Of Management And Outcomes Of Retroperitoneal Sarcoma: A Retrospective Cohort Study

Area of Science:

• Oncology
• Surgical Oncology
• Rare Cancers

Background:

• Retroperitoneal sarcomas (RPS) are rare, complex tumors requiring specialized surgical care.
• Outcomes for RPS are strongly linked to the quality of surgical intervention.
• Understanding patient demographics and treatment approaches is crucial for improving RPS management.

Purpose of the Study:

• To analyze patient demographics, treatment strategies, and outcomes for primary RPS.
• To evaluate surgical management and survival rates for RPS patients over a 10-year period.
• To assess the incidence of postoperative complications and recurrence rates in RPS.

Main Methods:

• Retrospective review of 54 RPS resections performed between 2010 and 2021.
• Data collection via histopathology, electronic care records, and chart review.
• Analysis of mortality rates, adverse events, resection margins, and survival data.

Main Results:

• A 10-year period saw 54 RPS resections with low 30-day (3.7%), in-hospital (1.9%), and 90-day (7.4%) mortality.
• 90.4% of patients achieved R0/R1 resection, with a 1-year survival of 80% and 5-year survival of 62%.
• 1 and 5-year cumulative incidence for local recurrence was 32% and 55%, respectively; distant metastases were 11% and 35%.

Conclusions:

• Survival outcomes for RPS at this center are comparable to high-volume centers globally.
• A low rate of severe postoperative complications was observed.
• Prospective data collection and multi-institution UK collaboration are essential for advancing RPS knowledge and patient care.