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Deciphering relationship between depression and microbial molecules based on multi-omics: A case study of Chaigui
Qi Wang1,2, Yingxia Zhao1,2, Xuemei Qin1,2
1Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China.
Chinese Herbal Medicines
|November 28, 2024
Summary
Chaigui Granules (CGKL) show antidepressant effects by regulating gut microbiota and arginine metabolism. This study reveals CGKL
Area of Science:
- Neuroscience
- Microbiology
- Pharmacology
Background:
- Depression is a complex disorder influenced by gut microbiota.
- Multi-omics approaches offer insights into the interplay between gut microbes and host physiology.
Purpose of the Study:
- To investigate the antidepressant effects of Chaigui Granules (CGKL).
- To elucidate the mechanism of CGKL involving gut microbiota and molecular pathways.
Main Methods:
- Chronic unpredictable mild stress (CUMS) model in rats.
- Behavioral tests and monoamine neurotransmitter analysis.
- 16S rRNA sequencing, LC-MS, qRT-PCR, and Western blotting.
Main Results:
- CGKL alleviated depressive behaviors and normalized neurotransmitter levels in a dose-dependent manner.
- CGKL improved gut microbiota arginine metabolism and regulated arginine levels in serum and hippocampus.
- CGKL modulated the expression of rate-limiting enzyme genes and proteins in the arginine pathway.
Conclusions:
- CGKL exhibits antidepressant properties.
- The mechanism involves regulating gut microbiota and arginine metabolism.
- CGKL's action is linked to modulating the arginine pathway and its associated enzymes.
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