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Updated: Jun 6, 2025

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

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Published on: October 31, 2013

Detecting DNA Translocation through a Nanopore using a van der Waals Heterojunction Diode.

Sihan Chen¹, Siyuan Huang², Jangyup Son^2,3

¹Holonyak Micro and Nanotechnology Laboratory, The Grainger College of Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.

Research Square

|November 28, 2024

Summary

This summary is machine-generated.

Researchers developed a new nanopore sensing method using 2D heterostructures for precise DNA analysis. This breakthrough enables out-of-plane electrical control of DNA translocation, advancing DNA sequencing technologies.

Keywords:

DNA Physical Sciences – Applied Physical Sciences ion transport nanopore single molecule van der Waals heterojunction

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Area of Science:

Nanotechnology
Materials Science
Biophysics

Background:

Solid-state nanopore sensing aims for out-of-plane electrical control of DNA during translocation for base-by-base sequencing.
Two-dimensional (2D) heterostructures offer atomic precision for constructing out-of-plane electronics, ideal for sensing membranes.

Purpose of the Study:

To demonstrate a novel nanopore architecture for out-of-plane electrical sensing and control of single DNA molecules.
To explore the use of 2D heterojunctions as electrical sensing membranes for biomolecule translocation.

Main Methods:

Fabrication of a vertical 2D heterojunction diode using p-type WSe2 on n-type MoS2.
Characterization of rectified interlayer tunneling currents and ionic transport modulation.
Concurrent detection of DNA translocation using ionic and diode currents.

Main Results:

Demonstrated a WSe2/MoS2 heterojunction diode exhibiting rectified interlayer tunneling currents modulated by ionic potential.
Showcased reciprocal rectification of ionic transport by the heterojunction potential.
Achieved concurrent detection of DNA translocation and a 2.3-fold electrostatic slowing of translocation speed.
Utilized encapsulation layers for robust operation and preserved spatial resolution of the 2D heterointerface.

Conclusions:

Established a new paradigm for out-of-plane electrical sensing and control of single biomolecules using 2D heterostructures.
The developed nanopore architecture enables precise manipulation and detection of DNA during translocation.
This work paves the way for advanced DNA sequencing technologies.