Jove
Visualize
Contact Us

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

162
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
162

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Courtship behaviour reveals temporal regularity is a critical social cue in mouse communication.

eLife·2023
Same author

The role of experience in prioritizing hippocampal replay.

Nature communications·2023
Same author

Behaviourally modulated hippocampal theta oscillations in the ferret persist during both locomotion and immobility.

Nature communications·2022
Same author

Experience-driven rate modulation is reinstated during hippocampal replay.

eLife·2022
Same author

The role of adaptation in generating monotonic rate codes in auditory cortex.

PLoS computational biology·2020
Same author

Tracking the Time-Dependent Role of the Hippocampus in Memory Recall Using DREADDs.

PloS one·2016
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 6, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.8K

Evaluating hippocampal replay without a ground truth.

Masahiro Takigawa1, Marta Huelin Gorriz1, Margot Tirole1

  • 1Institute of Behavioural Neuroscience (IBN), University College London (UCL), London, United Kingdom.

Elife
|November 28, 2024
PubMed
Summary

Researchers developed a novel framework to validate brain memory replay events. This method uses track discriminability to confirm if detected replays accurately reflect specific memories, overcoming the lack of external ground truth.

Keywords:
hippocampusmemoryneural decodingneuroscienceplace cellratreplaysleep

More Related Videos

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

12.7K
Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.8K

Related Experiment Videos

Last Updated: Jun 6, 2025

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice
07:10

Recording Spatially Restricted Oscillations in the Hippocampus of Behaving Mice

Published on: July 1, 2018

8.8K
Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus
09:59

Implantation of Chronic Silicon Probes and Recording of Hippocampal Place Cells in an Enriched Treadmill Apparatus

Published on: October 11, 2017

12.7K
Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit
11:37

Tuning in the Hippocampal Theta Band In Vitro: Methodologies for Recording from the Isolated Rodent Septohippocampal Circuit

Published on: August 2, 2017

9.8K

Area of Science:

  • Neuroscience
  • Cognitive Science
  • Computational Neuroscience

Background:

  • Memory traces are thought to be stabilized during rest and sleep through neural replay.
  • Replay is an internally generated process lacking an external ground truth for validation.
  • Current replay detection methods rely on sequence similarity to templates, posing evaluation challenges.

Purpose of the Study:

  • To introduce a new framework for evaluating the accuracy of memory replay detection.
  • To address the challenge of validating replay events without an external ground truth.
  • To assess the performance of replay detection methods in distinguishing between different memory traces.

Main Methods:

  • Developed a novel evaluation framework for neural replay detection.
  • Utilized hippocampal neural recordings from rats navigating two distinct linear tracks.
  • Implemented a two-track paradigm incorporating temporal fidelity (sequence-based detection) and track discriminability (sequenceless decoding).

Main Results:

  • The proposed framework successfully evaluated replay detection performance.
  • Track discriminability quantified the likelihood that a detected replay corresponded to a specific experienced track.
  • The method provides a quantifiable measure to assess the validity of inferred replay events.

Conclusions:

  • The new framework offers a robust method for evaluating memory replay detection.
  • This approach enhances the reliability of comparing and validating different replay detection algorithms.
  • The findings contribute to a better understanding of memory consolidation mechanisms during offline states.