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Published on: December 3, 2019
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Fluorescent nanoparticles from roast duck induce cell damage and physiological dysfunction in Caenorhabditis elegans
Guoxin Cui1,2,3,4,5, Shuang Cong6, Mingqian Tan1,2,3,4,5
1State Key Laboratory of Marine Food Processing and Safety Control, Dalian Polytechnic University, Dalian, China.
Journal of the Science of Food and Agriculture
|November 28, 2024
Summary
Fluorescent nanoparticles from food can enter the body. This study found they impact cell health and C. elegans development, highlighting the need for food safety assessments.
Area of Science:
- Nanotechnology
- Food Science
- Toxicology
Background:
- The safety of fluorescent nanoparticles (FNPs) ingested through food remains largely unknown.
- Investigating the biocompatibility of food-derived FNPs is crucial for public health.
Purpose of the Study:
- To assess the biocompatibility and potential toxicity of fluorescent nanoparticles (FNPs) derived from roast duck.
- To understand the impact of FNPs on cellular functions and organismal development.
Main Methods:
- Utilized pheochromocytoma (PC12) cells to evaluate cellular responses to FNPs.
- Employed Caenorhabditis elegans (C. elegans) as a model organism to study systemic effects and accumulation.
- Administered FNPs to C. elegans through their food source for exposure.
Main Results:
- FNPs induced early apoptosis, cell cycle alterations, increased reactive oxygen species, and reduced mitochondrial membrane potential in PC12 cells.
- FNPs permeated C. elegans via ingestion, accumulating in the intestine.
- FNPs affected C. elegans growth, reproduction, and motor behavior without causing mortality.
Conclusions:
- This research significantly enhances understanding of FNP safety in a food context.
- Findings provide a basis for risk assessment of foods containing FNPs.
- Offers guidance for ensuring food safety concerning nanoparticle ingestion.
