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IMPACT OF SARCOPENIA ON THE PROGNOSIS OF PATIENTS WITH CIRRHOSIS HOSPITALIZED FOR ACUTE DECOMPENSATION OR
Leticia Macedo Eifler1, Thaís Rodrigues Moreira1, João Pedro Pagani Possebon2
1Universidade Federal de Ciências da Saúde de Porto Alegre, Programa de Pós-Graduação em Medicina, Hepatologia, Porto Alegre, RS, Brasil.
Arquivos De Gastroenterologia
|November 28, 2024
Summary
This study found that sarcopenia did not significantly impact mortality in patients hospitalized with acute decompensation of cirrhosis. Sarcopenia prevalence was higher in those with acute-on-chronic liver failure, but this did not affect survival outcomes.
Area of Science:
- Hepatology
- Geriatrics
- Internal Medicine
Background:
- Cirrhosis is a major global health concern, contributing significantly to mortality.
- Sarcopenia, the loss of skeletal muscle mass and function, is increasingly recognized as a critical factor influencing patient prognosis in cirrhosis.
Purpose of the Study:
- To investigate the association between sarcopenia and mortality in patients hospitalized for acute decompensation of cirrhosis.
- To assess the impact of sarcopenia on prognosis, specifically in patients with or without acute-on-chronic liver failure.
Main Methods:
- A prospective cohort study involving patients hospitalized for acute decompensation of cirrhosis.
- Sarcopenia assessment utilized the European Working Group on Sarcopenia in Older People criteria, including bioelectrical impedance analysis and handgrip strength.
- Statistical analyses included Student's t-test, Mann-Whitney test, Chi-square test, Fisher's Exact test, and multivariate Poisson regression for risk estimation.
Main Results:
- The study included 50 patients; 50% were diagnosed with sarcopenia.
- Sarcopenia prevalence was higher in patients with acute-on-chronic liver failure (70.0%) compared to those without (43.2%), though this difference was not statistically significant (P=0.168).
- Overall mortality was 48% in sarcopenic patients and 44% in non-sarcopenic patients (P=1.000). Multivariate analysis identified leukocyte count and Model for End-stage Liver Disease score as significant predictors of mortality.
Conclusions:
- Sarcopenia was not found to be an independent predictor of mortality in patients hospitalized for acute decompensation of cirrhosis.
- A trend suggested a higher prevalence of sarcopenia in patients with acute-on-chronic liver failure, warranting further investigation.
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