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Regret in Clinical Trial Participation Among Cancer Patients.
Kayla M Baker1,2,3, Lucy Andersen1,2,3, Molly McHugh1,2,3
1University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania, USA.
Journal of Palliative Medicine
|November 28, 2024
Summary
Approximately 10% of cancer clinical trial participants reported regret. Younger age, greater symptom burden, and lower therapeutic optimism were linked to increased regret, impacting retention and ethical research.
Area of Science:
- Oncology
- Clinical Trials
- Patient-Reported Outcomes
Background:
- Cancer clinical trials (CCT) are crucial for advancing cancer care.
- Understanding patient experiences, including regret, is vital for ethical research and trial participation.
- Regret in CCT participation may influence patient retention and adherence.
Purpose of the Study:
- To examine the prevalence of regret among cancer clinical trial participants.
- To explore associations between regret and factors like symptom burden, symptom bother, therapeutic optimism, and spiritual beliefs.
- To identify predictors of regret in CCT participation.
Main Methods:
- Secondary analysis of cross-sectional data from American CCT patient-participants (2015-2019).
- Descriptive statistics, bivariate analyses, and logistic regression were employed.
- Sample size (n=325) was analyzed to evaluate regret.
Main Results:
- About 10% of participants reported regret.
- Younger age, increased symptom burden, increased symptom bother, and lower therapeutic optimism were significantly associated with regret (p < 0.05).
- Logistic regression identified younger age, symptom burden, and therapeutic optimism as significant predictors of regret (p < 0.05).
Conclusions:
- Regret is a relevant experience for a subset of cancer clinical trial participants.
- Symptom burden and therapeutic optimism are key factors influencing regret in CCT.
- Addressing patient symptom experiences and managing expectations may improve CCT retention and ethical research practices.
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