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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Related Experiment Video

Updated: Jun 6, 2025

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Interplay between Notch signaling and mechanical forces during developmental patterning processes.

Shahar Kasirer1, David Sprinzak2

  • 1School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel; Raymond and Beverly Sackler School of Physics and Astronomy, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 6997801, Israel.

Current Opinion in Cell Biology
|November 28, 2024
PubMed
Summary
This summary is machine-generated.

Cellular mechanics and biochemical signals, like Notch signaling, coordinate to shape developing tissues. This review explores how mechanical forces and cell differentiation interact to create unique biological patterns.

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Last Updated: Jun 6, 2025

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Area of Science:

  • Developmental biology
  • Cell biology
  • Biophysics

Background:

  • Biochemical signals and cell mechanics are increasingly recognized as key regulators of developmental patterning.
  • Notch signaling is a critical cell-cell communication pathway involved in many developmental processes.
  • The interplay between mechanical cues and cell differentiation is fundamental to tissue development and homeostasis.

Purpose of the Study:

  • To review the coordination between Notch signaling and cell mechanics in generating cellular patterns.
  • To discuss the reciprocal influence of mechanical cues and Notch-mediated differentiation.
  • To identify shared concepts and broader biological implications from diverse developmental systems.

Main Methods:

  • Literature review of recent studies.
  • Comparative analysis of developmental processes.
  • Synthesis of findings from mammalian inner ear, Drosophila, organoids, and zebrafish models.

Main Results:

  • Notch signaling and mechanical forces exhibit complex coordination in cellular patterning.
  • Mechanical cues can influence Notch-mediated differentiation and cell reorganization.
  • Cellular differentiation and reorganization can, in turn, affect mechanical properties and signaling.

Conclusions:

  • The integration of biochemical signaling (Notch) and cell mechanics is a unifying principle in developmental patterning.
  • Understanding this interplay offers insights into tissue development, homeostasis, and disease.
  • Cross-disciplinary approaches are crucial for deciphering these complex biological mechanisms.