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Hepatic Resection for Hepatocellular Carcinoma.

Parissa Tabrizian1, Adriana Pero2, Myron Schwartz1

  • 1Recanati-Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, 1 Gustave Levy Place, New York, NY 10029, USA.

Clinics in Liver Disease
|November 28, 2024
PubMed
Summary

Hepatic resection remains a key treatment for hepatocellular carcinoma (HCC), but its role is evolving with new therapies and changing patient demographics. Outcomes are improving with advancements in surgical criteria and systemic treatments.

Keywords:
Hepatic resectionHepatocellular carcinomaMilan criteria

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Area of Science:

  • Hepatobiliary surgery
  • Gastroenterology
  • Medical oncology

Background:

  • Hepatocellular carcinoma (HCC) treatment landscape is dynamic.
  • Surgical resection is a cornerstone for resectable HCC.
  • Evolving demographics and treatment options necessitate updated management strategies.

Purpose of the Study:

  • To review the current role and outcomes of hepatic resection for HCC.
  • To compare resection with liver transplantation and locoregional therapies.
  • To discuss the impact of new systemic therapies, complications, and recurrence management.

Main Methods:

  • Review of current literature on HCC treatment.
  • Analysis of changing HCC demographics.
  • Evaluation of surgical criteria and outcomes.
  • Assessment of novel systemic therapies, including immune checkpoint inhibitors.

Main Results:

  • Hepatic resection remains a preferred option for resectable HCC.
  • Liver transplantation and locoregional therapies offer alternative or adjuvant roles.
  • New systemic therapies, like immune checkpoint inhibitors, show promise in improving outcomes.
  • Understanding complications and recurrence patterns is crucial for patient management.

Conclusions:

  • The role of hepatic resection for HCC is evolving, influenced by demographics and new treatments.
  • Multidisciplinary approaches integrating surgery, transplantation, locoregional, and systemic therapies optimize HCC management.
  • Ongoing research is critical for improving survival and quality of life in HCC patients.