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PTPN23-dependent ESCRT machinery functions as a cell death checkpoint.

Dongyan Song1,2, Yuxin Cen1,2, Zhe Qian1,2

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.

Nature Communications
|November 28, 2024
PubMed
Summary

Protein tyrosine phosphatase non-receptor type 23 (PTPN23) acts as a cell death checkpoint. Its loss activates multiple cell death pathways by disrupting endosomal sorting of death receptors and toll-like receptors.

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