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A comparative study of theophylline in a slow-release 'sprinkle' format with a standard syrup preparation in young

K P Dawson

    Pharmatherapeutica
    |January 1, 1986
    PubMed

    Insights

    New slow-release theophylline sprinkles in children with asthma showed similar symptom control and compliance compared to liquid theophylline. However, the sprinkle formulation was linked to more side-effects and increased beta-agonist use.

    Area of Science:

    • Pediatric Pulmonology
    • Pharmacology
    • Clinical Therapeutics

    Background:

    • Asthma is a common chronic respiratory disease in children.
    • Theophylline is a bronchodilator used in asthma management.
    • Optimizing drug delivery and adherence is crucial for effective pediatric asthma care.

    Purpose of the Study:

    • To compare the efficacy and compliance of a new slow-release theophylline sprinkle formulation with conventional theophylline liquid in children with chronic asthma.
    • To assess the incidence of side-effects and the need for rescue medication in both treatment groups.

    Main Methods:

    • A randomized controlled trial involving 61 children with chronic asthma.
    • Participants received either theophylline sprinkles twice daily or theophylline liquid four times daily for three months.
    • Outcomes measured included compliance, symptom control, side-effects, and use of beta-agonist nebulization.

    Main Results:

    • No significant difference in compliance or asthma symptom control was observed between the sprinkle and liquid theophylline groups.
    • Patients receiving theophylline sprinkles experienced a higher incidence of side-effects.
    • The sprinkle group showed increased utilization of beta-agonist nebulization, suggesting potentially poorer symptom control or more frequent exacerbations.

    Conclusions:

    • The slow-release theophylline sprinkle formulation offers comparable efficacy and compliance to liquid theophylline in pediatric asthma.
    • The increased side-effect profile and higher beta-agonist use in the sprinkle group warrant further investigation.
    • Alternative formulations or closer monitoring may be necessary for theophylline sprinkles in this population.

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