[Preparations of matrix tablets from a polyacrylate base].

Area of Science:

• Pharmaceutical Sciences
• Polymer Chemistry
• Drug Delivery Systems

Context:

• Development of sustained-release drug formulations is crucial for improving therapeutic efficacy and patient compliance.
• Acrylate-based polymers offer versatile properties for designing drug delivery systems.
• Understanding drug release kinetics from matrix tablets is essential for formulation optimization.

Purpose:

• To investigate the preparation and drug release characteristics of acrylate-based matrix tablets.
• To analyze the drug release profiles using established kinetic models.
• To determine the influence of polymer composition and drug loading on drug release.

Summary:

• Acrylate-based matrix tablets were prepared using caffeine as a model drug.
• Drug release data were analyzed using Higuchi and Noyes-Whitney equations.
• Results indicate that both polymer composition and drug content significantly impact caffeine release from the matrix tablets.

Impact:

• Provides insights into the formulation of acrylate-based sustained-release tablets.
• Contributes to the understanding of factors governing drug release kinetics in matrix systems.
• Offers a foundation for designing tailored drug delivery systems with controlled release profiles.