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Post-translational modifications in drug resistance.

Chenggui Miao1, Yurong Huang2, Cheng Zhang3

  • 1School of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 999077, Hong Kong; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei 230012, China; Department of Pharmacology, School of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei 230012, China.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|November 29, 2024
PubMed
Summary

Protein post-translational modifications (PTMs) are key drivers of drug resistance across cancer, bacterial, and viral infections. Understanding these modifications offers new therapeutic targets to overcome treatment challenges.

Keywords:
AcetylationDrug resistanceGlycosylationPost-transcriptional modificationUbiquitination

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Drug resistance to anticancer, antimicrobial, and antiviral therapies significantly hinders treatment efficacy and patient outcomes.
  • Protein post-translational modifications (PTMs), including glycosylation, ubiquitination, and phosphorylation, are increasingly recognized as critical regulators of drug resistance.
  • These modifications involve the covalent addition of various molecules to proteins, influencing their function and stability within cellular signaling pathways.

Purpose of the Study:

  • To review the multifaceted roles of PTMs in the development of drug resistance.
  • To highlight PTMs as both inducers and potential targets for reversing drug resistance.
  • To provide insights into novel drug targets and treatment strategies for overcoming drug resistance.

Main Methods:

  • Literature review and synthesis of existing research on PTMs and drug resistance.
  • Analysis of PTM mechanisms in the context of antitumor, antimicrobial, and antiviral drug resistance.
  • Identification of specific PTMs implicated in resistance pathways.

Main Results:

  • PTMs are integral to antitumor drug resistance, acting as both drivers and potential targets for therapeutic intervention.
  • Bacteria employ diverse PTMs to mediate resistance to antimicrobial drugs.
  • Complex protein interaction networks induced by PTMs contribute to antiviral drug resistance.

Conclusions:

  • PTMs play a crucial role in diverse drug resistance mechanisms, impacting cancer, bacterial, and viral diseases.
  • Targeting PTMs presents a promising avenue for developing novel strategies to combat drug resistance.
  • Further research into PTMs can guide the development of improved therapeutic plans and drug targets.