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Modulation of the ubiquitin-proteasome system by curcumin: Therapeutic implications in cancer

Shima Yahoo Torghabe1, Parisa Alavi2, Sara Rostami3

  • 1Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran.

Pathology, Research and Practice
|November 29, 2024
PubMed

Insights

Curcumin, a dietary compound, shows promise in cancer treatment by targeting the ubiquitin-proteasome pathway. It influences key cellular processes to suppress cancer growth and induce cell death.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Cellular protein degradation is primarily managed by the ubiquitin-proteasome system.
  • Dysregulation of the ubiquitination pathway is linked to various cancer types.
  • Dietary phytochemicals are emerging as potential anti-cancer agents.

Purpose of the Study:

  • To investigate the role of curcumin in modulating the ubiquitin-proteasome pathway for cancer suppression.
  • To explore curcumin's potential as a therapeutic agent in cancer treatment.

Main Methods:

  • Analysis of curcumin's effects on ubiquitin-proteasome pathway components.
  • Investigation of curcumin's impact on cellular processes like NF-κB signaling, cyclin inhibition, and apoptosis induction.

Main Results:

  • Curcumin was found to interfere with critical reactions within the ubiquitin-proteasome pathway.
  • Curcumin demonstrated the ability to modulate NF-κB signaling.
  • Curcumin induced apoptosis and inhibited cyclins, key factors in cell cycle regulation.

Conclusions:

  • Curcumin exhibits significant potential in suppressing carcinogenesis by targeting the ubiquitin-proteasome pathway.
  • Curcumin's multifaceted effects on cellular processes suggest its viability as a potential anti-cancer drug.
Keywords:
CancerPrteasomeTumorgenesisTurmericUPS pathwayUbiquitination

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