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Aspergillus spondylodiscitis successfully treated with a long course of isavuconazole

Francisco Javier Teigell Muñoz1, Ana Sánchez-de Torre2, Marta Jiménez-Fernández3

  • 1Internal Medicine Department, Infanta Cristina University Hospital, Madrid, Spain.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|November 29, 2024
PubMed

Insights

This case study demonstrates successful treatment of Aspergillus spondylodiscitis using isavuconazole when voriconazole was not tolerated. Isavuconazole offers a promising alternative for invasive aspergillosis with fewer side effects.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Aspergillus spondylodiscitis is a rare, severe invasive aspergillosis form.
  • Voriconazole is the standard first-line treatment for Aspergillus osteomyelitis and spondylodiscitis.

Observation:

  • A patient with Aspergillus spondylodiscitis experienced severe intolerance to voriconazole.
  • Isavuconazole was administered as an alternative antifungal therapy.

Findings:

  • The patient was successfully treated with isavuconazole, demonstrating its efficacy.
  • Isavuconazole exhibited good tolerability, with fewer adverse effects compared to voriconazole.

Implications:

  • Isavuconazole presents a viable alternative for invasive aspergillosis, particularly spondylodiscitis, when voriconazole is contraindicated.
  • This case contributes to the limited but growing evidence supporting isavuconazole's use in complex fungal infections.
  • Further research is warranted to establish isavuconazole's role in treating Aspergillus spondylodiscitis.
Keywords:
Antifungal therapyAspergillus fumigatusInvasive aspergillosisIsavuconazoleOsteomyelitisSpondylodiscitis

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