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Related Experiment Video

Updated: Jun 6, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release

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Polydisperse Versus Monodisperse Microbubbles: A Simulation Study for Contrast-Enhanced Ultrasound Imaging.

Agisilaos Matalliotakis¹, Martin D Verweij²

¹Section of Medical Imaging, Department of Imaging Physics, Faculty of Applied Sciences, Delft University of Technology, Delft, The Netherlands.

Ultrasound in Medicine & Biology

|November 29, 2024

Summary

Monodisperse microbubbles (MBs) offer superior contrast enhancement in ultrasound imaging compared to polydisperse MBs. However, these monodisperse MBs also amplify non-linear imaging artifacts, potentially misclassifying them as tissue.

Keywords:

Acoustic simulations Contrast-enhanced ultrasound Deep tissue imaging INCS Microbubbles Monodisperse Multiple scattering Non-linear imaging artifacts Non-linear oscillations Polydisperse

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Synthesis and Characterization of Multi-Modal Phase-Change Porphyrin Droplets

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Published on: October 15, 2021

Area of Science:

Medical Imaging
Acoustics
Biophysics

Background:

Contrast-enhanced ultrasound (CEUS) utilizes microbubbles (MBs) for enhanced vascular visualization and organ perfusion.
Novel monodisperse MB formulations are being developed to improve upon traditional polydisperse MBs for more consistent imaging outcomes.

Purpose of the Study:

To investigate the contrast enhancement properties of various-sized monodisperse MBs.
To analyze the influence of monodisperse MBs on non-linear imaging artifacts in CEUS.
To compare the performance of monodisperse versus polydisperse MBs in simulated ultrasound environments.

Main Methods:

Numerical simulations using the iterative non-linear contrast source (INCS) method were employed.
The INCS method realistically simulated ultrasound propagation in both monodisperse and polydisperse MB populations.
Individual bubble properties and multiple scattering effects were considered in the simulations.

Main Results:

Scattering from resonant monodisperse MBs was 11.8 dB stronger than from polydisperse MBs.
Non-linear imaging artifacts downstream of monodisperse MBs were 19.4 dB stronger compared to polydisperse suspensions.
Monodisperse MBs demonstrated a higher signal-to-noise ratio.

Conclusions:

Monodisperse MBs are more effective contrast agents in CEUS, particularly at resonance.
Enhanced non-linear wave propagation artifacts occur with monodisperse MBs.
These artifacts can lead to misclassification of MBs as tissue in CEUS imaging.