Determination of larger urinary peptides in osteoarthrosis by high-performance liquid chromatography

Urinary peptides larger than 4000 were fractionated by HPLC on reversed phase. Urines of osteoarthrotic patients were compared with those of healthy persons and rheumatoid patients. The profile of urinary peptides of patients with mild form of osteoarthrosis differed significantly from that of other groups studied. The results of patients with rheumatoid arthritis were similar to those of patients with activated or severe form of osteoarthrosis.