Recurrent Inflammatory Reaction to Laryngeal Hyaluronic Acid Injection
Hannah Kreuser1, Kenneth C Fletcher2, Ruth J Davis1
1Division of Otolaryngology-Head & Neck Surgery, Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.
The Annals of Otology, Rhinology, and Laryngology
|November 30, 2024
Summary
Recurrent inflammatory reactions after hyaluronic acid (HA) vocal fold injection, even with steroids, can occur. Hyaluronidase injection successfully prevented further reactions in a unique case.
Area of Science:
- Otolaryngology
- Vocal fold physiology
- Injectable fillers
Background:
- Hyaluronic acid (HA) fillers are common for glottic insufficiency.
- While generally safe, 3-5% of patients experience rare inflammatory reactions.
- Corticosteroids typically resolve these reactions without recurrence.
Purpose of the Study:
- To report a unique case of recurrent inflammatory reactions post-laryngeal HA injection.
- To describe a novel management strategy for such complications.
Main Methods:
- Retrospective review of a single patient's medical record.
- Detailed description of the patient's presentation and treatment course.
Main Results:
- A 42-year-old female experienced recurrent inflammatory reactions and airway symptoms post-HA injection, unresponsive to corticosteroids.
- Hyaluronidase injection was administered to dissolve residual HA.
- This intervention successfully prevented further inflammatory reactions.
Conclusions:
- Recurrent inflammatory reactions following HA injection are possible despite corticosteroid treatment.
- Hyaluronidase offers a novel therapeutic approach for managing these rare complications.
- This case expands understanding of HA filler adverse events and their management.
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