Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light-Inducible Activation of FGFR3 Facilitates Chondrocyte Maturation.

Cell proliferation·2026
Same author

Lung-Targeted HGF mRNA Restores Alveolar Structure in Experimental Emphysema.

The European respiratory journal·2026
Same author

Development and validation of an echocardiographic nomogram for identifying cardiac amyloidosis in patients with left ventricular hypertrophy.

BMC cardiovascular disorders·2025
Same author

iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation.

Gut·2025
Same author

Knowledge, attitude and practice of pregnant women towards pre-eclampsia in Chongqing, China.

BMJ open·2025
Same author

The Synchrony of STARD4-AS1 and H19 Downregulation with Cardiomyocytes Cell Cycle Arrest.

Biology of the cell·2025
Same journal

A DLP-Printed 3D Bioceramplug Fabricated Using a Photocurable Negative Thermo-Responsive Bioceramic Slurry for Cranial Burr-Hole Repair.

ACS biomaterials science & engineering·2026
Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026
Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same journal

Biomimetic 3D-Printed Resorbable Extracellular Matrix-Guided Bone Regeneration Membrane Based on a Gelatin Methacrylate/Alginate-Hydroxyapatite Composite for Maxillofacial Surgery.

ACS biomaterials science & engineering·2026
Same journal

Sequential Biofunctionalization of a Choline-Based Monomeric Ionic Liquid and Polymerized Ionic Liquid: A Route to Dual Anionic Drug Polymer Conjugates of Piperacillin-Tazobactam.

ACS biomaterials science & engineering·2026
Same journal

Retinoic Acid-Functionalized Chitosan Polycationic Conjugates for Integrated Melanoma Therapy and Antibacterial Infection Control.

ACS biomaterials science & engineering·2026
See all related articles

Related Experiment Video

Updated: Jun 6, 2025

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.2K

Progress in Biomaterials-Enhanced Vascularization by Modulating Physical Properties.

Hao Li1, Dayan Li1, Xue Wang1,2

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Clinical Stem Cell Research Center, Peking University Third Hospital, Peking University, Beijing 100191, China.

ACS Biomaterials Science & Engineering
|November 30, 2024
PubMed
Summary
This summary is machine-generated.

Optimizing biomaterial physical properties like pore structure, surface topography, and stiffness is key for promoting vascularization. This enhances nutrient and oxygen delivery, improving tissue engineering and clinical applications.

Keywords:
Material modificationPhysical propertyRegenerative medicineTissue engineeringVascularization

More Related Videos

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.4K
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

20.9K

Related Experiment Videos

Last Updated: Jun 6, 2025

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
07:56

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo

Published on: August 28, 2014

12.2K
Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.4K
Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration
09:23

Engineering 3D Cellularized Collagen Gels for Vascular Tissue Regeneration

Published on: June 16, 2015

20.9K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Vascularization is essential for nutrient and oxygen supply in biomaterials.
  • Optimal physical properties of biomaterials can enhance vascularization.
  • Improved vascularization leads to better outcomes in tissue engineering and clinical translation.

Purpose of the Study:

  • To review the effects of biomaterial physical properties on vascularization.
  • To highlight the role of pore structure, surface topography, and stiffness in promoting angiogenesis.
  • To discuss the potential of enhanced vascularization in various regenerative medicine applications.

Main Methods:

  • Literature review focusing on physical properties of biomaterials.
  • Analysis of studies investigating the relationship between biomaterial characteristics and vascularization.
  • Synthesis of findings related to pore structure, surface topography, and stiffness.

Main Results:

  • Biomaterial pore structure influences cell infiltration and vascular network formation.
  • Surface topography can guide endothelial cell alignment and blood vessel development.
  • Biomaterial stiffness plays a critical role in mechanotransduction pathways that promote angiogenesis.

Conclusions:

  • Tailoring biomaterial physical properties is crucial for promoting effective vascularization.
  • Enhanced angiogenic capability in biomaterials can lead to improved standardized research models.
  • This approach offers potential for personalized treatment strategies in bone regeneration, wound healing, islet transplantation, and cardiac repair.