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Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

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Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution

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Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects.

Davide D'Angelo¹, Eride Quarta¹, Gianluca Bazzoli¹

¹Department of Food and Drug Sciences, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.

International Journal of Pharmaceutics

|November 30, 2024

Summary

Aqueous tablet coating can cause increased porosity and cracks due to water interactions. Tablet component mechanical properties significantly influence these structural changes, impacting final product quality.

Keywords:

Aqueous coating Compression Environmental sustainability Micro-computed tomography

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Aqueous tablet coating is an eco-friendly alternative to organic solvent-based coatings.
Water-based coatings may introduce quality issues like increased porosity and cracking due to component-water interactions.

Purpose of the Study:

To investigate the structural behavior of drug-excipient mixtures during compression and aqueous coating.
To evaluate the impact of tablet component mechanical properties on structural integrity after coating.

Main Methods:

Compression of quaternary mixtures (model drug and three excipients).
Coating with hypromellose aqueous solution and enteric coating.
Porosity measurement using X-Ray microcomputed tomography (XµCT) at each stage.

Main Results:

XµCT revealed significant structural changes in some tablets post-coating.
Porosity increased by up to 12% in certain formulations.
Tablet components exhibiting significant plastic densification showed greater structural changes, including swelling and cracking.

Conclusions:

The mechanical properties of tablet components are critical in determining structural changes during aqueous coating.
XµCT is an essential tool for detecting morphological alterations that can affect tablet quality.
Careful selection of excipients is necessary to mitigate quality issues in aqueous tablet coating.