Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study

Area of Science:

• Gastroenterology
• Hematology
• Inflammatory Bowel Disease Research

Background:

• Ulcerative colitis (UC) is a chronic inflammatory condition of the large intestine.
• Coagulation abnormalities are increasingly recognized in patients with UC.

Purpose of the Study:

• To investigate the role of coagulation parameters in assessing ulcerative colitis severity.
• To evaluate specific markers like D-dimer, FDP, and FIB in UC patients.

Main Methods:

• Analysis of 364 ulcerative colitis patients (163 female, 201 male).
• Assessment of disease activity using Truelove and Witts criteria.
• Measurement of fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).

Main Results:

• Elevated D-dimer, FDP, and FIB levels were observed in severe UC cases compared to non-severe cases.
• D-dimer demonstrated significant diagnostic potential with an AUC of 0.852.
• D-dimer and FIB showed positive correlations with inflammatory markers CRP and ESR.

Conclusions:

• D-dimer, FDP, and FIB are identified as potential biomarkers for determining ulcerative colitis disease severity.
• These markers may aid in clinical decision-making and patient management for UC.