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Saprochaete capitata Infection in Teen With Acute Myeloid Leukemia Receiving Echinocandin Prophylaxis
Jordan Killingsworth1, Rachel Boren2, Rachna Sheth3
1Department of Internal Medicine-Pediatrics, McGovern Medical School at UTHealth Houston, Houston, Texas, USA.
Abstract:
We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a Saprochaete capitata disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.
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