Factor XIII Deficiency Presenting With Duodenal Hematoma in a 3-Year-Old Female: A Comprehensive Radiological...

Area of Science:

• Pediatric Hematology
• Rare Bleeding Disorders

Background:

• Factor XIII (FXIII) deficiency is a rare inherited bleeding disorder.
• Typical pediatric presentations include umbilical stump bleeding, soft tissue hemorrhage, and poor wound healing.
• Atypical presentations can pose diagnostic challenges.

Purpose of the Study:

• To report an atypical presentation of FXIII deficiency in a pediatric patient.
• To emphasize the importance of considering rare bleeding disorders in children with non-specific symptoms.

Main Methods:

• Case report of a 3-year-old female presenting with abdominal pain and vomiting.
• Clinical evaluation and management by the pediatric surgery team.
• Review of typical and atypical FXIII deficiency presentations.

Main Results:

• The patient presented with symptoms not commonly associated with FXIII deficiency.
• Conservative management was initiated by the pediatric surgery team.
• This case underscores the variability in FXIII deficiency manifestation.

Conclusions:

• FXIII deficiency can manifest atypically in children, presenting with gastrointestinal symptoms.
• Early recognition and appropriate management are crucial for favorable outcomes.
• This case broadens the understanding of FXIII deficiency's clinical spectrum in pediatrics.