Related Experiment Video
Updated: Jun 6, 2025

The Tail Suspension Test
Published on: January 28, 2012
Decrease in Serum Lithium Levels Induced by Ursodeoxycholic Acid: A Case Report
Gizem Gulpamuk1, Kursat Altinbas1
1Department of Psychiatry, Selcuk University, Konya, Turkey.
Abstract:
Lithium is a leading therapeutic option for bipolar patients in the treatment of acute and maintenance phases of illness. Lithium levels should be closely monitored due to its narrow therapeutic index. Combination of other treatment regimens with lithium may increase or decrease lithium levels that may cause intoxication symptoms or recurrence of mood episodes. Therefore, clinicians should be aware of the drugs recommended by other medical specialties that may change lithium plasma levels. Nonsteroidal anti-inflammatory drugs, thiazide diuretics, and angiotensin-converting enzyme inhibitors are the best known potential medicines for drug interactions with lithium. In this article, we aimed to present a case report of a patient who was taking lithium for recurrent depression more than 3 years with stable serum levels, but lithium levels decreased fastly after the prescription of ursodeoxycholic acid. The possible mechanism of interaction between lithium and ursodeoxycholic acid was discussed with the current literature.
More Related Videos
10:25Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
Published on: November 22, 2024
08:42Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
Related Concept Videos
Mania and Antimanic Drugs: Overview
Hepatic Drug Excretion: Influencing Factors
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Drugs for Treatment of Constipation-Predominant IBS
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...