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Design Strategies and Application Potential of Multifunctional Hydrogels for Promoting Angiogenesis.
Menglei Wang1, Jiawen Chen1, Yawen Luo1
1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
International Journal of Nanomedicine
|December 3, 2024
Summary
This review details functional hydrogels designed to promote angiogenesis, highlighting their diverse properties and applications in tissue regeneration and disease treatment. Future directions for these advanced biomaterials are also proposed.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Hydrogels are versatile platforms for biomedical applications due to their tunable properties.
- Promoting angiogenesis is crucial for tissue repair and regeneration.
- A comprehensive review on hydrogels specifically designed to enhance angiogenesis is needed.
Purpose of the Study:
- To systematically review functional hydrogels designed for promoting angiogenesis.
- To summarize design strategies and properties of these hydrogels.
- To discuss their applications in wound healing, bone regeneration, and myocardial ischemia.
Main Methods:
- Comprehensive literature review of functional hydrogels promoting angiogenesis.
- Analysis of hydrogel properties including anti-oxidant, substance-delivery, stimulus-responsive, self-healing, conductive, and wound-monitoring capabilities.
- Discussion of hydrogel applications in various biomedical contexts.
Main Results:
- Functional hydrogels can be rationally designed with specific properties to promote angiogenesis.
- Diverse design strategies yield hydrogels with anti-oxidant, drug-delivery, and responsive features.
- These hydrogels show promise in wound healing, bone regeneration, and treating myocardial ischemia.
Conclusions:
- Functional hydrogels represent a promising strategy for enhancing angiogenesis in biomedical applications.
- Further research into novel design strategies and applications is warranted.
- These biomaterials offer potential for treating angiogenesis-related diseases.
