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Updated: Jun 6, 2025
Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
Two-step tandem synthesis of sugar-containing pyrimidine derivatives catalyzed by Lipozyme® TL IM in continuous-flow
Han-Jia Xie1, Wen-Xuan Shao1, Li-Hua Du1
1College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou 310014 Zhejiang China orgdlh@zjut.edu.cn +86 571 88320903 +86-189-690-693-99.
Abstract:
A novel series of sugar-containing pyrimidine derivatives have been synthesized via an effective and convenient two-step tandem synthesis in continuous-flow microreactors with excellent regioselectivity. Using continuous-flow microreactors to assemble two-step reactions into one unit can effectively avoid separating and purifying intermediates. Moreover, this method allows the optimization of reaction parameters for each unit individually. The salient features of this method include a reduction in the use of DMSO and mild reaction conditions (30-40 °C). Under the optimum reaction conditions, we can obtain the desired yield (34.8-69.1%) in a shorter time (40 min) than the shaking condition (48 h).
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