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Updated: Jun 6, 2025
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
Clinically Implemented Sensing-Based Initial Programming of Deep Brain Stimulation for Parkinson's Disease: A
Bart E K S Swinnen1, Andrea Fuentes1, Monica M Volz1
1University of California San Francisco Department of Neurology, University of California San Francisco, San Francisco, CA, USA; University of California San Francisco Weill Institute for Neurosciences, Movement Disorders and Neuromodulation Centre, University of California San Francisco, San Francisco, CA, USA.
Sensing-based deep brain stimulation (DBS) programming for Parkinson's disease (PD) is feasible and efficient. This neurophysiology-guided approach significantly improved motor symptoms and reduced medication needs, offering a faster alternative to traditional methods.
Area of Science:
- Neurology
- Neurosurgery
- Biomedical Engineering
Background:
- Traditional deep brain stimulation (DBS) programming for Parkinson's disease (PD) is lengthy and subjective.
- Neurophysiological feedback offers potential for more objective and efficient DBS programming.
Purpose of the Study:
- To evaluate the feasibility and performance of sensing-based initial DBS programming for PD.
- To compare sensing-based programming with conventional monopolar review.
Main Methods:
- A retrospective study involving 15 PD patients (25 hemispheres) using sensing-enabled neurostimulators.
- Initial DBS programming guided by real-time beta power in local field potential recordings.
Main Results:
- Sensing-based programming averaged 42.2 minutes per hemisphere, eliminating the need for monopolar review.
- Clinically effective contacts were identified in most patients, including those with tremor.
- Significant improvements were observed in motor function (MDS-UPDRS III) and a reduction in medication requirements at one year post-surgery.
Conclusions:
- Sensing-based initial DBS programming for PD is feasible, rapid, and effective.
- This method successfully identified effective stimulation contacts in the majority of patients.
- Technological advancements may further enhance sensing-based DBS programming.
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