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Rat models of frozen shoulder: Classification and evaluation
Hezirui Gu1,2, Wenqing Xie1,3, Hengzhen Li1,3
1Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Animal Models and Experimental Medicine
|December 4, 2024
Summary
Frozen shoulder (FS), or adhesive capsulitis, causes shoulder stiffness and pain. This review examines various rat models to better understand FS pathogenesis and develop effective treatments for this debilitating condition.
Area of Science:
- Orthopedics
- Rheumatology
- Animal Models
Background:
- Frozen shoulder (adhesive capsulitis) is characterized by shoulder stiffness and pain, significantly impacting quality of life.
- The exact mechanisms of frozen shoulder are not fully understood, and current treatments vary in efficacy.
- Early diagnosis is challenging due to overlapping symptoms with other shoulder conditions.
Purpose of the Study:
- To review existing rat models for frozen shoulder research.
- To analyze the advantages, disadvantages, and applicability of different modeling techniques.
- To provide insights into understanding FS pathogenesis and developing treatment strategies.
Main Methods:
- Review of external immobilization models.
- Review of surgical internal immobilization models.
- Review of injection and endocrine modeling models.
Main Results:
- Detailed description of four main types of FS rat models.
- Comparative analysis of the suitability of each model for FS research.
- Summary of common evaluation methods for FS rat models.
Conclusions:
- Rat models are crucial for elucidating frozen shoulder pathogenesis.
- Understanding these models aids in developing targeted prevention and treatment strategies.
- Further research using validated animal models is needed to improve clinical outcomes for frozen shoulder patients.
