Multi-modal Medical Image Fusion Approach Utilizing Gradient Domain Guided Image Filtering
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Updated: Jun 20, 2026

Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development
Published on: April 10, 2016
Menghui Sun1, Xiaoliang Zhu1, Yunzhen Niu1
1School of Software, Xinjiang University, Ürümqi, 830008, China.
Background:
Currently, most multimodal medical image fusion techniques focus solely on integrating the edge details of image features, often overlooking color preservation from the source images. Hence, this paper proposes a multi-channel fusion algorithm based on gradient domain-guided image filtering.
Purpose:
This study aims to enhance the color preservation of source images in multimodal medical image fusion algorithms.
Methods:
Utilizing gradient field-guided image filters for image smoothing, the process involves constructing different image layers, decomposing using wavelet transforms, and downsampling. Various fusion rules are then applied before inverse wavelet transformation.
Results:
Regarding MSE, CCI, PSNR, SSIM, DD, SM, and other metrics, the proposed algorithm consistently ranks highest compared to alternative methods.
Conclusion:
Through both subjective and objective analyses, experimental results substantiate the significant edge-preserving effects of the proposed fusion algorithm while effectively maintaining image fidelity and spectral integrity.
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