Synergistic Effect of Dual-Focus Soft Contact Lenses and 0.05% Atropine on Myopia Control in Children With Rapidly
Hae Ri Yum1, So Young Han, Shin Hae Park
1Department of Ophthalmology (H.R.Y.), Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea; Department of Ophthalmology (S.Y.H.), Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; and Department of Ophthalmology (S.H.P., S.Y.S.), Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Insights
Dual-focus soft contact lenses (CLs) combined with 0.05% atropine effectively control myopia progression in children. This combination therapy showed greater benefits for low to moderate myopia cases compared to high myopia.
Area of Science:
- Ophthalmology
- Pediatric Optometry
- Myopia Management
Background:
- Myopia is a growing public health concern in children.
- Effective myopia control strategies are crucial to prevent high myopia and associated ocular pathologies.
- Current treatments include low-dose atropine and specialized contact lenses.
Purpose of the Study:
- To evaluate the combined efficacy of dual-focus soft contact lenses (CLs) and 0.05% atropine in managing childhood myopia.
- To compare the outcomes of combination therapy versus atropine monotherapy.
- To assess the differential effects of combination therapy based on myopia severity.
Main Methods:
- Retrospective analysis of 142 myopic children (7-13 years).
- Initial treatment with 0.05% atropine for myopia progression > -1.00 D/year.
- Addition of dual-focus soft CLs for those with continued progression (>0.75 D/year or axial elongation >0.25 mm/year).
- Comparison between monotherapy and combination groups, with subgroups for low/moderate and high myopia.
Main Results:
- Combination therapy significantly slowed myopia progression and axial elongation (P=0.001, P=0.012).
- No significant difference in progression between groups after CLs were added.
- Axial elongation inhibition was more pronounced in the low/moderate myopia subgroup (P=0.028).
Conclusions:
- Combination of dual-focus soft CLs and 0.05% atropine is effective for controlling rapidly progressing myopia in children.
- The additive effect of combination therapy is more significant in children with low/moderate myopia.
- This strategy offers a promising approach for comprehensive myopia management.
Objectives:
The aim of this study was to evaluate the combined effect of dual-focus soft contact lenses (CLs) and 0.05% atropine in the control of myopia.
Methods:
A retrospective study was conducted on 142 myopic children aged 7 to 13 years. A single nightly instillation of 0.05% atropine at bedtime was prescribed if the rate of myopia progression exceeded -1.00 D/year. After 1 year of treatment, patients who exhibited myopia progression of more than 0.75 D/year or an increase in axial length of more than 0.25 mm/year were additionally treated with dual-focus soft CLs (MiSight) alongside 0.05% atropine (Combination group, n=71). By contrast, patients who showed myopia progression of less than 0.50 D/year and axial elongation of less than 0.20 mm/year continued treatment with 0.05% atropine only (Monotherapy group, n=71). Subjects in the combination group were further divided into high myopia and low/moderate myopia subgroups, using a cutoff of -6 D.
Results:
Myopia progression and axial elongation were significantly slower after the addition of dual-focus soft CLs to 0.05% atropine in the combination group ( P =0.001 and P =0.012, respectively). The combination group exhibited statistically significantly faster myopia progression than the monotherapy group before the addition of dual-focus soft CLs (both P <0.001), but no significant difference in myopia progression between the two groups was observed afterward ( P =0.504 and P =0.479, respectively). The inhibition of axial elongation was more pronounced in the low/moderate myopia group compared with the high myopia group ( P =0.028).
Conclusions:
The combination of dual-focus soft CLs and 0.05% atropine is an effective treatment strategy for controlling myopia in children with rapidly progressing myopia. The additive effect was greater in children with low/moderate myopia than in those with high myopia.
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