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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
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Relationship Between Whole Blood Iron Levels and Lipid Profile Parameters in the General Population: Findings from
Rou-Jun Pan1, Zhi Luo1, Yu-Shun You1
1School of Medicine, Taizhou University, No. 1139 Shifu Avenue Jiaojiang, 318000, Taizhou, Zhejiang, China.
Biological Trace Element Research
|December 4, 2024
Summary
High whole blood iron levels correlate positively with total cholesterol, triglycerides, and LDL cholesterol in a Chinese community population. Regulating iron may help manage dyslipidemia, particularly triglycerides, especially in men.
Area of Science:
- Biochemistry
- Clinical Medicine
- Public Health
Background:
- Dyslipidemia is a prevalent health issue linked to various diseases and ferroptosis.
- While dyslipidemia and ferroptosis are connected, the relationship between blood lipid parameters and whole blood iron levels remains unclear.
- Iron is a key factor in ferroptosis, and lipid profiles are key indicators of dyslipidemia.
Purpose of the Study:
- To investigate the association between whole blood iron levels and blood lipid profiles in a community-based population in Taizhou, China.
- To determine if whole blood iron levels can serve as a predictive indicator for dyslipidemia.
Main Methods:
- Cross-sectional study involving 1917 community residents in Taizhou, China.
- Measurement of serum levels for total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and whole blood iron.
- Pearson correlation analysis was employed to assess the relationship between variables.
Main Results:
- A significant positive correlation was observed between whole blood iron concentration and total cholesterol, triglycerides, and low-density lipoprotein cholesterol in both genders (P < 0.001).
- No significant correlation was found between whole blood iron and high-density lipoprotein cholesterol (P = 0.618, P = 0.083).
- The positive correlation between whole blood iron and triglycerides was most pronounced (P < 0.001, r = 0.138), with trends being more significant in men.
Conclusions:
- Regulating whole blood iron levels may represent a potential strategy for managing dyslipidemia, specifically targeting triglycerides, total cholesterol, and low-density lipoprotein cholesterol in the Taizhou population.
- The potential for controlling triglycerides by modulating whole blood iron levels is particularly noteworthy.
- Findings have implications for dyslipidemia prevention and diagnosis, especially for male residents.
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