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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Ru(III)-PhI(OAc)2─A Combination for Generation of Isocyanate Intermediate from Benzimidate through a Rearrangement:
Shobhon Aich1, Mriganka Saha1, Debasish Ghosh1
1Department of Chemistry, University of Calcutta, 92 A. P. C. Road, Kolkata-700009, India.
Abstract:
Ru(III)-PhI(OAc)2, an unprecedented combination, is a highly efficient reagent system for the in situ generation of a valuable isocyanate intermediate from benzimidate synthons through a rearrangement. It unlocks a powerful platform for forming diverse C-N bonds, enabling the one-pot synthesis of an expansive array of valuable unsymmetrical ureas, carbamates, and their chiral analogues toward complex molecular structures with high selectivity and excellent yields. This new strategy not only exemplifies efficiency but also serves as a versatile tool for the construction of valuable molecular architectures, enhancing the scope and impact of modern synthetic chemistry.
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